The implementation of artificial intelligence (AI) assistance in pathology has been shown to significantly reduce the risk of immunohistochemistry (IHC) use per detected case of sentinel node (SN) metastasis, resulting in cost savings and time efficiency. In a single-center prospective trial, AI-assisted pathologists spent less time assessing hematoxylin and eosin (HE) slides of SN specimens and had higher sensitivity and negative predictive values for detecting micrometastases and macrometastases. The study also found that AI assistance prevented the use of IHC for detecting micrometastases and reduced the cost of IHC use per detected case of SN metastasis.

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